Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Does not meet important criteria of todays standard methods

Data source

Reference
Title:
Unnamed
Year:
1927

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroaniline
EC Number:
202-426-4
EC Name:
2-chloroaniline
Cas Number:
95-51-2
Molecular formula:
C6H6ClN
IUPAC Name:
2-chloroaniline
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
cat
Sex:
female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
unchanged (no vehicle)
Doses:
approx. 125 and 305 mg/ kg bw (single injection site)
in a second test a total dose of 125 mg/kg bw was injected at 8 different sites
No. of animals per sex per dose:
1 female cat per dose
Control animals:
no

Results and discussion

Effect levels
Dose descriptor:
other: lethal dose
Effect level:
305 mg/kg bw
Remarks on result:
other: approximate dose

Applicant's summary and conclusion