Registration Dossier
Registration Dossier
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EC number: 202-426-4 | CAS number: 95-51-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated
Data source
Reference
- Reference Type:
- publication
- Title:
- Environmental chemical permeation of bovine ocular lens capsule
- Author:
- Ismail, R et al.
- Year:
- 1 976
- Bibliographic source:
- Chemosphere, 2: 145-150
Materials and methods
- Type of study / information:
- permeation of bovine lens in vitro
- Principles of method if other than guideline:
- permeation of bovine lens in vitro
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chloroaniline
- EC Number:
- 202-426-4
- EC Name:
- 2-chloroaniline
- Cas Number:
- 95-51-2
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 2-chloroaniline
- Details on test material:
- no data
Constituent 1
Results and discussion
Any other information on results incl. tables
At an initial concentration of 0.026%, 16 and 45% permeation
was measured after 3 and 24 hours, respectively (50% meaning
equilibrium between outer and inner compartment). Aldolase and malate
dehydrogenase activity were reduced by o-chloroaniline whereas glucose-6
-phosphate dehydrogenase and glutamate-pyruvate-transaminase activity
were increased.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
