Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-110-0 | CAS number: 924-88-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 January 2002 to 30 January 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedures according to national standard, no GLP, no chemical analysis and moderate documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ÖNORM EN ISO 6341
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Diisopropyl succinate
- EC Number:
- 213-110-0
- EC Name:
- Diisopropyl succinate
- Cas Number:
- 924-88-9
- Molecular formula:
- C10H18O4
- IUPAC Name:
- diisopropyl succinate
- Details on test material:
- - Name of test material: Diisopropylsuccinat
- Amount: ca. 50 mL
- Storage: at 4°C until the investigation
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substance was dilluted in deionised water (Millipore ELIX 10) immediately before the start of the test. The pH value was adjusted with NaOH or H2SO4 to 7.8 +- 0.2.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS (HFA-stem C1)
- Age at study initiation: 1 to 24 hours
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- no data
- Test temperature:
- 20 +- 2°C
- pH:
- the pH value was adjusted with NaOH or H2SO4 to 7.8 +- 0.2.
- Dissolved oxygen:
- no data
- Salinity:
- not applicable.
- Nominal and measured concentrations:
- Nominal concentrations: 0; 0.2; 0.3 and 0.4 mL/L corresponding to (density of the test substance = 0.9847 g/cm3) 0.0; 197; 295 and 394 mg/L in the main experiment and 0; 0.1; 0.5 and 1.0 mL/L corresponding to (density of the test substance = 0.9847 g/cm3) 0.0; 98; 492 and 985 mg/L in a preliminary experiment.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: no data
- No. of vessels per concentration (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- no data
OTHER TEST CONDITIONS
- Adjustment of pH: yes
- Photoperiod: The test was conducted in the dark.
EFFECT PARAMETERS MEASURED :Immobilisation % after 24 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2
- Range finding study: A preliminary study using nominal concentrations of 0; 98; 492 and 985 mg/L was conducted and 0; 0; 100; and 100 % immobilisation was observed respectively. The results of the preliminary study were used for determination of the concentrations for the main experiment as well as for the determination of the EC50 of the whole investigation. - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.3 other: mL/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- For immobilisation see table 1.
- Behavioural abnormalities: not stated
- Mortality of control: 0%
- Other adverse effects control: not stated
- Abnormal responses: not stated
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no - Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- no data
Any other information on results incl. tables
Table 1: Immobilisation
Test substance concentration (mg/L) | 0 | 98 | 197 | 295 | 394 | 492 | 985 |
immobilisation 24 hours in %, preliminary study | 0 | 0 | not tested | not tested | not tested | 100 | 100 |
immobilisation 24 hours in %, main study | 0 | not tested | 70 | 65 | 95 | not tested | not tested |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 24 hours > nominal 100 mg/L
- Executive summary:
The immobilisation data from the preliminary test and the main experiment were used for the determination of the EC50 24 hours. The EC50 24 hours is nominal greater than 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.