Registration Dossier
Registration Dossier
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EC number: 201-855-4 | CAS number: 88-74-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 10 mg/m³
- Study duration:
- subacute
- Species:
- rat
Additional information
In oral repeated administration a NOEL of 50 mg/kg bw/day was determined from a 9 weeks study. The major treatment -related effects are clinical signs, but not methemoglobinemia, and weight loss. In a vapour inhalation 28 day assay a NOAEC was determined at 10 mg/m3 in rats, due to slight methemoglobinemia and haematological effects seen at 90 mg/m3.
No specific target organ for systemic toxicity could be identified for the oral route. For the inhalation route, haematology findings are considered the most relevant.
Repeated dose toxicity: inhalation - systemic effects (target organ) cardiovascular / hematological: other
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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