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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Method: other: Noakes and Sanderson, 1969. Observation period 9 days.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Alcohols, C12-16
EC Number:
272-490-6
EC Name:
Alcohols, C12-16
Cas Number:
68855-56-1
IUPAC Name:
tetradecan-1-ol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall), Breeding Unit,  Sittingbourne, Kent, UK
- Age at study initiation: 12 weeks


Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: not reported applied to shorn dorsolumbar skin
- Type of wrap if used: aluminium foil and waterproof plaster

REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with tepid dilute detergent solution.
- Time after start of exposure: 24 hours

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 and 4 ml/kg (830 and 3320 mg/l using the specific gravity  reported of 0.83)
- Concentration (if solution): undiluted

Duration of exposure:
24 hours
Doses:
830 and 3320 mg/kg
No. of animals per sex per dose:
2M, 2F
Control animals:
no
Details on study design:
- Duration of observation period following administration: 9 days
- Frequency of observations and weighing: mortality and clinical signs during the 9 day observation period

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 320 mg/kg bw
Mortality:
All animals survived the 9 day observation period.
Clinical signs:
No signs of intoxication.
Body weight:
Not reported.
Gross pathology:
Not carried out.
Other findings:
POTENTIAL TARGET ORGANS: None identified.
SEX-SPECIFIC DIFFERENCES: No.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Rat dermal LD50 >3320 mg/kg (24 hour occluded). There were no signs of toxicity.