Alcohols, C12-15-branched and linear

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Principles of method if other than guideline:

Method: other: Noakes and Sanderson, 1969. Observation period 9 days.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C12-16

EC Number:

272-490-6

EC Name:

Alcohols, C12-16

Cas Number:

68855-56-1

IUPAC Name:

tetradecan-1-ol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall), Breeding Unit,  Sittingbourne, Kent, UK
- Age at study initiation: 12 weeks

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: not reported applied to shorn dorsolumbar skin
- Type of wrap if used: aluminium foil and waterproof plaster

REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with tepid dilute detergent solution.
- Time after start of exposure: 24 hours

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 and 4 ml/kg (830 and 3320 mg/l using the specific gravity  reported of 0.83)
- Concentration (if solution): undiluted

Duration of exposure:

24 hours

Doses:

830 and 3320 mg/kg

No. of animals per sex per dose:

2M, 2F

Control animals:

no

Details on study design:

- Duration of observation period following administration: 9 days
- Frequency of observations and weighing: mortality and clinical signs during the 9 day observation period

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 3 320 mg/kg bw

Mortality:

All animals survived the 9 day observation period.

Clinical signs:

other: No signs of intoxication.

Gross pathology:

Not carried out.

Other findings:

POTENTIAL TARGET ORGANS: None identified.
SEX-SPECIFIC DIFFERENCES: No.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Rat dermal LD50 >3320 mg/kg (24 hour occluded). There were no signs of toxicity.