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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 May - 26 May 1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
internal BASF-Test: single dose group exposed to 2000 mg/kg bw comparable to limit test, observation period 15 d
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
3,7-Dimethyloctadien-2,6-al-1
Purity: >= 95 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Wiga
- Weight at study initiation: males 185.3 g, females 168.3 g

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: back skin

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.32-0.38 g




Duration of exposure:
24 h
Doses:
2000 mg/kg
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 15 days
- Frequency of observations: 1, 5, 6, 7, 8, 11, 12, 13, 14 and 15 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: single tested dose
Sex:
male/female
Dose descriptor:
LD0
Effect level:
2 000 mg/kg bw
Remarks on result:
other: single tested dose
Mortality:
No mortality
Clinical signs:
No clinical signs of acute toxicity
Body weight:
No information available
Gross pathology:
Nothing abnormal detected
Other findings:
Local skin effects: initially slight signs of primary irritation of the skin observed; during 14 days observation period development of desquamation

Applicant's summary and conclusion