Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
08 Aug - 22 Aug 1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Internal BASF test: Inhalation hazard test according to Smith et al. (1962)
GLP compliance:
no
Test type:
other: inhalation hazard test
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
3,7-Dimethyloctadien-2,6-al-1
Purity: >= 95 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: males 165 g, females 149 g

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- A saturated atmosphere was generated by bubbling 200l/h air at 20 ° C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 hours.

TEST ATMOSPHERE
- No analytical determination of the atmosphere concentration was performed. The nominal concentration was calculated as the quotient of the amount of test substance weight loss during the exposure and the amount of air used during the exposure.


Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
7 h
Concentrations:
Enriched atmosphere (0.68 mg/L = 680 mg/m3) generated by passing 200 L air/hr through a 5 cm thick layer of the test substance at 20° C
No. of animals per sex per dose:
12 in total
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Observations: only on day 1
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Mortality:
No mortality
Clinical signs:
Nothing abnormal detected
Body weight:
At the end of the study: males 264 g, females 187 g
Gross pathology:
Nothing abnormal detected

Any other information on results incl. tables

No mortality observed after 7 hours of exposure to an atmosphere enriched with the volatile parts of the compound at 20°C.

Applicant's summary and conclusion