Citral

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

08 Aug - 22 Aug 1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Internal BASF test: Inhalation hazard test according to Smith et al. (1962)

GLP compliance:

no

Test type:

other: inhalation hazard test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Citral

EC Number:

226-394-6

EC Name:

Citral

Cas Number:

5392-40-5

Molecular formula:

C10H16O

IUPAC Name:

3,7-dimethylocta-2,6-dienal

Constituent 2

Reference substance name:

(Z)-3,7-dimethylocta-2,6-dienal

EC Number:

203-379-2

EC Name:

(Z)-3,7-dimethylocta-2,6-dienal

Cas Number:

106-26-3

Molecular formula:

C10H16O

IUPAC Name:

(2Z)-3,7-dimethylocta-2,6-dienal

Details on test material:

3,7-Dimethyloctadien-2,6-al-1
Purity: >= 95 %

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males 165 g, females 149 g

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- A saturated atmosphere was generated by bubbling 200l/h air at 20 ° C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 hours.

TEST ATMOSPHERE
- No analytical determination of the atmosphere concentration was performed. The nominal concentration was calculated as the quotient of the amount of test substance weight loss during the exposure and the amount of air used during the exposure.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

Enriched atmosphere (0.68 mg/L = 680 mg/m3) generated by passing 200 L air/hr through a 5 cm thick layer of the test substance at 20° C

No. of animals per sex per dose:

12 in total

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Observations: only on day 1
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Mortality:

No mortality

Clinical signs:

other: Nothing abnormal detected

Body weight:

At the end of the study: males 264 g, females 187 g

Gross pathology:

Nothing abnormal detected

Any other information on results incl. tables

No mortality observed after 7 hours of exposure to an atmosphere enriched with the volatile parts of the compound at 20°C.