Registration Dossier

Diss Factsheets

Administrative data

Description of key information

-Skin irritation: not irritating, not corrosive in vitro
-Eye irritation: severely irritant in vitro

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

In the available relevant in vitro results obtained with the reaction mass containing mainly 2-chloropropene, it was demonstrated that the reaction mass was

-not irritant in the skin irritation test

-not corrosive in the skin corrosion test

-severely irritant or corrosive in the bovine corneal opacity and permeability test.

No information is available on the respiratory irritation for the reaction mass containing mainly the 2-chloropropene. However, as the 3-chloropropene which is one of the substance constituting the mixture is officially classified as a respiratory irritant (STOT SE 3/H335 according to CLP legislation), it was taken into account to propose the classification.

Effects on eye irritation: highly irritating

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Skin and Eye irritation:

Based on the above in vitro results, we propose the following classification:

-R36 (irritating to eyes) according to DSD legislation

-Eye irritation Cat 2/H319 (Causes serious eye irritation) according to CLP legislation.

No classification is needed for the skin irritation endpoint.

Respiratory irritation:

Depending on the batch, the proportion of some of the impurities as 3 -chloropropene may vary. Some of the samples contains up to 0.5% in 3-chloropropene while other contains up to 5% of the same substance. As the percentage of 3-chloropropene reach maximum 5%, we should not classified the reaction mass containing mainly 2-chloropropene for this endpoint according to the mixtures's criterias of CLP-DSD legislation.