Alcohols, C16-18, ethoxylated

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04 - 18 Nov 1986

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

adopted in 1981

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Hexadecan-1-ol

EC Number:

253-149-0

EC Name:

Hexadecan-1-ol

Cas Number:

36653-82-4

Molecular formula:

C16H34O

IUPAC Name:

hexadecan-1-ol

Constituent 2

Reference substance name:

2-(hexadecyloxy)ethanol

EC Number:

218-373-5

EC Name:

2-(hexadecyloxy)ethanol

Cas Number:

2136-71-2

Molecular formula:

C18H38O2

IUPAC Name:

2-(hexadecyloxy)ethanol

Constituent 3

Reference substance name:

2-[2-(Hexadecyloxy)ethoxy]ethanol

EC Number:

610-892-9

Cas Number:

5274-61-3

Molecular formula:

C20H42O3

IUPAC Name:

2-[2-(Hexadecyloxy)ethoxy]ethanol

Constituent 4

Reference substance name:

2-[2-[2-(Hexadecyloxy)ethoxy]ethoxy]ethanol

Cas Number:

4484-59-7

Molecular formula:

C22H46O

IUPAC Name:

2-[2-[2-(Hexadecyloxy)ethoxy]ethoxy]ethanol

Constituent 5

Reference substance name:

2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethanol

Cas Number:

5274-63-5

Molecular formula:

C24H50O5

IUPAC Name:

2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethanol

Constituent 6

Reference substance name:

Octadecan-1-ol

EC Number:

204-017-6

EC Name:

Octadecan-1-ol

Cas Number:

112-92-5

Molecular formula:

CH3(CH2)17OH

IUPAC Name:

octadecan-1-ol

Constituent 7

Reference substance name:

2-(octadecyloxy)ethanol

EC Number:

218-374-0

EC Name:

2-(octadecyloxy)ethanol

Cas Number:

2136-72-3

Molecular formula:

C20H42O2

IUPAC Name:

2-(octadecyloxy)ethanol

Constituent 8

Reference substance name:

2-[2-(Octadecyloxy)ethoxy]ethanol

EC Number:

605-213-8

Cas Number:

16057-43-5

Molecular formula:

C22H46O3

IUPAC Name:

2-[2-(Octadecyloxy)ethoxy]ethanol

Constituent 9

Reference substance name:

2-[2-[2-(Octadecyloxy)ethoxy]ethoxy]ethanol

EC Number:

610-180-8

Cas Number:

4439-32-1

Molecular formula:

C24H50O

IUPAC Name:

2-[2-[2-(Octadecyloxy)ethoxy]ethoxy]ethanol

Constituent 10

Reference substance name:

2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethanol

Cas Number:

59970-10-4

Molecular formula:

C26H54O5

IUPAC Name:

2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethanol

Constituent 11

Reference substance name:

2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol

Cas Number:

71093-13-5

Molecular formula:

C28H58O6

IUPAC Name:

2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol

Test material form:

liquid

Test animals

Species:

rat

Strain:

other: Bor:WISW (SPF TNO)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Weight at study initiation: 107 g
- Housing: 1 - 5 animals in Macrolon cages (type III)
- Diet: R10 Alleindiät für Ratten, Ssniff Spezialfutter GmbH, Soest, Germany, ad libitum
- Water: Tap water, ad libitum
- Fasting period before study: 16 h
- Acclimation period: 4 - 8 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: From: 14 Nov 1986 To: 18 Nov 1986

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 11.905 mL/kg bw

DOSAGE PREPARATION: The test substance was heated to 50 °C and applied undiluted by oral gavage.

Doses:

10000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing: prior to dosing and on Days 1, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred.

Clinical signs:

other: The only clinical sign of toxicity was piloerection. 2 h after dosing all animals were free of clinical signs.

Gross pathology:

No effects were observed.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.

Conclusions:

For the test substance a LD50 (rat, m/f) > 10000 mg/kg bw was determined in a study according to OECD guideline 401.