Registration Dossier
Registration Dossier
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EC number: 700-802-7 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
For REACH registration of Polyamine Acetates cross-reading is proposed with information from the relevant members of the category of the Polyamines.
The Polyamine Acetates are being produced by adding Acetate to the Polyamine substances, and as such could also be considered a preparation of both substances.
As a consequence the composition of the products reflect the same variation with considerable overlap with respect to their content of primary amines, diamine, triamines and tetraamines.
Due to dissociation in the course of the gastrointestinal tract, a principal difference in their toxicological profile compared to the Polyamines without the acetate for systemic toxicity cannot be expected. However as the acetate group is added to increase water solubility of the compound, and influences the pH of the substance, some differences could occur in the toxicity profile for acute toxicity and local effects.
Full justification for cross-reading can be found in the document attached to Chapter 13 of this IUCLID: "Category approach justification for polyamine acetates 29 03 2012.pdf".
Since the volumes that are put on the market are below 10 ton/a no risk assessment and therefore no DNELS are required.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Since the volumes that are put on the market are below 10 ton no risk assessment and therefore no DNELS are required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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