Registration Dossier
Registration Dossier
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EC number: 217-421-2 | CAS number: 1843-05-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The toxicokinetic behavior was investigated in a feeding study in rats (Patel 1968). Groups of rats were given either a control diet or a diet containing 1.25 or 5.0% octabenzone daily for 35 days. Separate portions of each urine sample were analyzed for octabenzone in the free form and as the glucuronide conjugate. Daily samples of urine and feces were collected from each animal. Two animals from each group were sacrificed on Days 11, 22, and 35, and liver and kidney tissues were taken for microscopic examinations. In urine samples, glucuronic acid was determined before and after hydrolysis with beta-glucuronidase. Urinary octabenzone was calculated from the increased amount of glucuronic acid found after hydrolysis, assuming an equimolar relationship between the two. Fecal levels of octabenzone were based on the increased weight of evaporated acetone extracts of feces, since octabenzone is highly soluble in acetone. Paper chromatography and spectrophotometric analysis were used to establish that 10% of the dose appeared as conjugated octabenzone in the urine, and that the remainder was eliminated unchanged in the feces. It is concluded that octabenzone does not have a potential for bioaccumulation.
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