2-vinylpyridine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Older Russian industrial hygiene and toxicology studies do not use international guideline methods, and insufficient data is presented on methods to determine whether they are valid.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

On the Toxicology of 2-Vinyl Pyridine

Author:

Dukhovnaya AI

Year:

1966

Bibliographic source:

Gigiena truda (Occupational Hygiene) 3:9-13

Materials and methods

Principles of method if other than guideline:

Methodology is not well described in this 1966 study. Exposure of mice occurred in poisoning chambers filled with 2VP vapours. Concentration of the vapour was measured.

GLP compliance:

not specified

Test type:

other: accepted experimental protocol used in Russian scientific institutes

Test material

Test material information

Constituent 1

Reference substance name:

2-vinylpyridine

EC Number:

202-879-8

EC Name:

2-vinylpyridine

Cas Number:

100-69-6

Molecular formula:

C7H7N

IUPAC Name:

2-ethenylpyridine

Details on test material:

Described as a dark brown oily liquid with a pungent and irritating odor. The molecular weight was 105, specific gravity of 0.97 at 20 degrees C, boiling point of 158 degrees C at 760 mm Hg.

Test animals

Species:

mouse

Details on test animals or test system and environmental conditions:

Vapors introduced into poisoning chambers.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Details on inhalation exposure:

Described as a one-time dynamic poisoning over 4 hours

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Statistics:

Probit analysis in order to arrive at an inhalation LC50

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

0.46 mg/L air (analytical)

Exp. duration:

4 h

Remarks on result:

other: +/- 1 SD is 200-900 mg/l

Mortality:

50% of animals

Clinical signs:

other: Narcotic effect

Applicant's summary and conclusion

Interpretation of results:

Category 1 based on GHS criteria

Remarks:

Migrated information

Conclusions:

The inhalation LC50 for 2-vinylpyridine in white mice was found experimentally to be 0.46 mg/liter. While this study does not not have sufficient documentation to allow for its unrestricted use, the findings are generally consistent with those using standard OECD-type protocols, hence suggesting it is valid. As in vivo inhalation toxicity testing is not planned due to the corrosive nature of the test material, this study provides a baseline estimate of the inhalatory toxicity of 2VP.