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Diss Factsheets
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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The physical and chemical properties of 2-Vinylpyridine (2VP) determine its environmental fate. The substance is a liquid with a vapour pressure of 25 hPa, so it is moderately volatile. If it is released to air, 2VP reacts rapidly with atmospheric hydroxyl radicals, nitric oxide radicals and ozone, with a half-life of 1-2 hours. 2VP is not expected to contribute substantially to air contamination nor to terrestrial toxicity originating from atmospheric sources.
2VP is highly water soluble, at 27,500 mg/l. It has a Henry’s Law constant of 1.4 x 10-5atm m3/mol, suggesting that when 2VP is released to water, it has a limited tendency to partition to the air. The alkene moiety renders it resistant to hydrolysis.
However, this alkene is reactive and accounts for its functionality as an initiator of polymerisation reactions. It is commercially supplied with a polymerization inhibitor. In the absence of inhibitor, it rapidly autopolymerises or forms reaction products with available acidic or electrophilic substances, and can result in a self-accelerating exothermic reaction. The reactivity of 2VP is also reflected in its corrosive nature of 2VP in biological systems. When 2VP is placed in a dilute solution, polymerization is initiated and rapidly progresses. The calculated Kocvalue of 66 does not reflect this reactivity.
In several different experimental protocols, 2VP has demonstrated poor biodegradability; it is neither readily nor inherently biodegradable in standard tests. A value of 0% degradation was obtained in the inherent biogegradability assay in which test conditions prevented loss by volatilization. This low rate of biodegradation likely resulted from the dilution of the polymerisation inhibitor in the test media, allowing autopolymerization and/or reaction of 2VP with components of the media. Therefore, while biodegradation was not demonstrated in the biodegradation assays, neither has it been shown that 2VP concentrations remain stable over the timecourse of the test. As a conservative approach, 2VP is being classified as Persistent.
2-Vinylpyridine is not bioaccumulative, and is therefore not of with concern to food chain exposures (secondary poisoning) or PBT classification.
In conclusion, 2VP is conservatively classified as persistent in the aquatic environment, although this is likely due to polymerization or complexation. It is not of concern for atmospheric or terrestrial exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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