Registration Dossier
Registration Dossier
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EC number: 202-547-2 | CAS number: 96-96-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- combined repeated dose and carcinogenicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : BZ7175000; Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases.
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);V.1-36, 1957-1992. MTPEEI Volume(issue)/page/year: 32(3),48,1988
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- RTECS database
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 5-nitro-o-anisidine
- EC Number:
- 202-770-5
- EC Name:
- 5-nitro-o-anisidine
- Cas Number:
- 99-59-2
- IUPAC Name:
- 2-methoxy-5-nitroaniline
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 30D
- Frequency of treatment:
- intermittent
Results and discussion
Results of examinations
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- Liver - liver function tests impaired Liver - changes in liver weight Blood - other changes
Effect levels
- Dose descriptor:
- other: TDLo
- Effect level:
- 13 500 other: mg/kg/30D
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
