Registration Dossier
Registration Dossier
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EC number: 904-304-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on a Stimulation Index of 5.5 at the high concentration of Crude 1,3-dichloropropene of 50% v/v, Crude 1,3-dichloropropene is considered to be a skin sensitizer in the LLNA. However, the limitations of the LLNA only allow prediction of the induction phase.
Migrated from Short description of key information:
Crude 1,3-dichloropropene was evaluadted for the potential to induce skin sensitization in an O.E.C.D. Testing Guideline 429 mouse local lymph node assay (LLNA) with GLP compliance.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data. Not a required endpoint for a Transported Intermediate dossier (E.C.H.A. Guidance for Intermediates. February 2008).
Justification for classification or non-classification
Based on the positive findings from a mouse local lymph node assay, Crude 1,3 -dichloropropene requires Classification and Labeling as a skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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