Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Endpoint summary
Administrative data
Description of key information
Additional information
SUMMARY AQUATIC TOXICITY
Acute aquatic data is available for fish, daphnia and algae, all studies showing methodological and documentary deficiencies, hence the majority of them considered to be of reliability 3:
In one 96h flow-through exposure study on fish, the LC50 value was found to be 0.93 mg/L (analytical), at the margin of the maximum water solubility of carbazole. All other concentrations below failed to produce signs of intoxication in this investigation (Brooke 1991).
It is suggestive that the presence of acetonitrile as auxilliary agent biassed the inherent properties of carbazole. The respective static study (also in the presence of unspecified solvent) resulted in an LC40 of 1.14 mg/L (40 % mortality).
Due to the limited documentation, no firm conclusion about the validity of these result can be drawn.
A second study in fish, the LC50(48 h) was found to be 2.5 mg/L in a semi-static study using carp (CERI/MITI 1999).
An early limited feeding study using carp (Loeb and Kelly 1963) gave no evidence of acute intoxication of force-fed carp after 70 h, with an ED0 of 195 mg/kg bw.
In two acute studies on daphnia, the EC50 values were very similar at about 3.2 mg/L (analytical). T
he lowest NOEC was 0.4 mg/L (analytical) in algae; no EC50 value was derivable in this study.
In a second algal study, the EC50(72 h) was far above water solubility.
Overall, the results indicate that, in general, based on the weight of evidence, the EC50/LC50 values are above the maximum water solubility of about 1 mg/L.
Hence, no classification as to aquatic toxicity is indicated.
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