Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
In a growth inhibition test with Scenedesmus acuminatus, an EC10 of > 0.4 mg/L (analytical) was determined. This represents a NOEC of 0.4 mg/L.
Key value for chemical safety assessment
Additional information
To assess the toxicity of carbazole to aquatic algae one valid study using the green algae Scenedesmus acuminatus is available (van Vlaardingen 1996). A second study (Sagner 2009) resulted in an EC50 value significantly above the maximum water solubility probably due to the use of DSMO as disolution aid.
Van Vlaardingen 1996
In this growth inhibition test, the green algae Scenedesmus acuminatus is used. The test does not follow a specific guideline but is similar to OECD test guideline 201. For carbazole, an EC10 of > 0.4 mg/L (analytical) was determined. Results for the highest dose tested (1 mg/L, nominal) were ambiguous. Growth effects in one experiment could not be reproduced in a replicate test. In addition, a measured test substance concentration in the test culture (0.48 mg/L) indicated the presence of an undissolved portion of test substance. Overall, based on these results, exposure concentrations of carbazole up to the maximum water solubility are unlikely to produce significant acute toxicity as to reach EC50 values. This is confirmed by the finding of Sanger 2009.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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