Registration Dossier
Registration Dossier
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EC number: 203-931-2 | CAS number: 112-05-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- no guideline required
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nonanoic acid
- EC Number:
- 203-931-2
- EC Name:
- Nonanoic acid
- Cas Number:
- 112-05-0
- Molecular formula:
- C9H18O2
- IUPAC Name:
- nonanoic acid
- Details on test material:
- - Name of test material (as cited in study report): pelargonic acid, nonanoic acid
- Analytical purity: purest quality commercially available
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- other: in vitro perfused liver
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 mM
- No. of animals per sex per dose / concentration:
- 4 per group
- Control animals:
- yes, concurrent vehicle
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- not specified
Any other information on results incl. tables
Liver perfusion with a 5 mM solution of the test substance increased the amount of ß-hydroxybutyrate, acetoacetate and glucose. acetoacetate. The formation of ketone bodies (sum of ß-hydroxybutyrate and acetoacetate) increased (and also the ratio of hydroxybutyrate to acetoacetate). The following table shows the corresponding mean values and standard deviations.
ß-hydroxybutyrate (µmol/h/g) |
Acetoacetate (µmol/h/g) |
Total ketone bodies formation (µmol/h/g) |
Glucose (µmol/h/g) |
|
Control |
19.6 ± 1.9 |
10.8 ± 0.9 |
30.4 ± 3.3 |
8.4 ± 1.6 |
5 mM |
47.3 ± 7.6 |
32.8 ± 4.2 |
103 ± 12 |
16.8 ± 1.8 |
Applicant's summary and conclusion
- Conclusions:
- The test substance produced biochemical alterations in the perfused rat liver.
- Executive summary:
The perfusion of rat liver with a 5 mM solution of the test substance increased the amount of ß-hydroxybutyrate, acetoacetate and glucose. The formation of ketone bodies increased as well as the ratio of hydroxybutyrate to acetoacetate (Krebs, 1970).
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