Registration Dossier
Registration Dossier
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EC number: 617-345-3 | CAS number: 82543-14-4
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2001-03-13 to 2001-03-14
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- yes
- Remarks:
- Comment: Since the vapor pressure was expected to be very low, a mixture of substances was examined. If the vapor pressure of the mixture did not exceed a certain value, this would also be valid for every single substance.
- GLP compliance:
- yes
- Type of method:
- effusion method: vapour pressure balance
Test material
- Reference substance name:
- 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one
- EC Number:
- 617-345-3
- Cas Number:
- 82543-14-4
- Molecular formula:
- C25H36O4
- IUPAC Name:
- 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one
Constituent 1
Results and discussion
Vapour pressure
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.001 Pa
Applicant's summary and conclusion
- Executive summary:
The vapor pressure of ZK 90504 was determined using a screening method based on the
detection of the evaporation rate from a Knudsen cell of a vapor pressure balance at 25 °C.
Since simplified experimental conditions are also acceptable within the scope of this project, ZK
90504 was mixed with four other compounds. From all five test substances low or very low
vapor pressures, based on the study director´s experience, were expected. For this reason the
experiments consisted in the measurement of the evaporation rate of the mixture from a
Knudsen cell at 25 °C. Since the evaporation rate of the mixture was below the value derived
from the lower limit of the vapor pressure range recommended for the use of a vapor pressure
balance (1E-03 Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure of the
mixture is lower than 1E-03 Pa.
Considering this fact, the vapor pressure of the single compounds in the mixture has also to be
lower than 1E-03 Pa. Therefore, the vapor pressure of ZK 90504 can be estimated to be at 25 °C:
p25 < 1E-03 Pa
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