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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
other information
Study period:
2000-08-25
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pretest quality data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Screening method based on the detection of the beginning of precipitate formation upon
portion-wise addition of an organic solution of the respective test substance under continuous
stirring into an excess volume of water while maintaining a temperature range of 25 to 30 °C.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one
EC Number:
617-345-3
Cas Number:
82543-14-4
Molecular formula:
C25 H36 O4
IUPAC Name:
5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one

Results and discussion

Water solubility
Water solubility:
0.006 g/L
Temp.:
25 °C
Remarks on result:
other: pH not measured

Applicant's summary and conclusion

Executive summary:

The water solubility of ZK 90504 was determined in "pretest quality" to be

0.006 g/L

using a screening method based on the detection of the beginning of precipitate formation upon

portion-wise addition of an organic solution of the respective test substance under continuous

stirring into an excess volume of water while maintaining a temperature range of 25 to 30 °C.

Due to the specifics of the screening method, the above value is expected to represent an upper

limit which should not be exceeded by the test substance in its crystalline form.

The solubility of ZK 90504 is well below the lower limit set by the VCI guidance of 0.1 g/l.

Therefore no further measurements are necessary within the scope of this study.

ZK 90504 is to be considered as practically insoluble or insoluble in water.