Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-544-9 | CAS number: 1609-86-5
Endpoint summary
Administrative data
Description of key information
In a valid oral toxicity study a LD50 = 185 mg/kg bw for rats (male) was found
2 acute inhalation toxicity studies are available:
In the key study according OECD 403 for male + female rats a LC50 = 1593 mg/m³ air (analytical vapour concentration) was found. In an inhalation-hazard test rats were placed in a 10 l glass chamber and were exposed whole body for 3 or 10 min to the vapour of tert-butylisocyanate and were observed for 14 d after the exposure to the test substance. 3 min. exposure: 5/5 males died within 4 minutes after start of exposure; 4/5 females died within 6-12 minutes after start of exposure, signs of irritation were found; 10 min.exposure: all rats died within 4 minutes after start of exposure, signs of irritation were found.
No study was available for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 185 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 593 mg/m³ air
Additional information
In a reliable oral toxicity studies a LD50 of 185 mg/kg bw on male rats were found.
In a guideline study according OECD 403 for male and female rats a LC50 = 1593 mg/m³ air (analytical vapour concentration) was found.
For acute dermal toxicty no data were available.
Justification for classification or non-classification
For the acute oral toxicity a classification as T, R25 justified as a result of the LD50 = 185 mg/kg bw
For the acute inhalation toxicity T, R23 is justified as a result of the LC50 = 1593 mg/m³ air
In addition, respiration irritational effects were reported. Therefore R 37 is applicable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
