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Description of key information

In a valid oral toxicity study a LD50 = 185 mg/kg bw  for rats (male) was found
2 acute inhalation toxicity studies are available:
In the key study according OECD 403 for male + female rats a LC50 = 1593 mg/m³ air (analytical vapour concentration) was found. In an inhalation-hazard test rats were placed in a 10 l glass chamber and were exposed whole body for 3 or 10 min to the vapour of tert-butylisocyanate and were observed for 14 d after the exposure to the test substance. 3 min. exposure: 5/5 males died within 4 minutes after start of exposure; 4/5 females died within 6-12 minutes after start of exposure, signs of irritation were found;  10 min.exposure: all rats died within 4 minutes after start of exposure, signs of irritation were found.
No study was available for acute dermal toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
185 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
1 593 mg/m³

Additional information

In a reliable oral toxicity studies a LD50 of 185 mg/kg bw on male rats were found.

In a guideline study according OECD 403 for male and female rats a LC50 = 1593 mg/m³ air (analytical vapour concentration) was found.

For acute dermal toxicty no data were available.

Justification for classification or non-classification

For the acute oral toxicity a classification as T, R25 justified as a result of the LD50 = 185 mg/kg bw

For the acute inhalation toxicity T, R23 is justified as a result of the LC50 = 1593 mg/m³ air

In addition, respiration irritational effects were reported. Therefore R 37 is applicable

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