Registration Dossier

Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 26, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: EU test method L383 A/54-62 (EEC A.6)
Deviations:
no
Principles of method if other than guideline:
The flask method is used for determination of 1-octanol solubility. In this method, the substance dissolved in 1-octanol at a temperature somewhat above the test temperature. When saturation is achieved the mixture is cooled and kept at the test temperature, stirring as long as necessary to reach equilibrium. Subsequently, the mass concentration of the substance in the supernatant aqueous solution, which must not contain any undissolved particles, is determined by a suitable analytical method.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Amides, C12-18 (even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl)
IUPAC Name:
Amides, C12-18 (even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl)
Test material form:
liquid: viscous
Remarks:
Light yellow

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Remarks:
1-octanol
Remarks on result:
other: Test substance is miscible in 1-octanol in all proportions
Details on results:
The test material is mixable with 1-octanol in all proportions

Any other information on results incl. tables

Preliminary test:

For this purpose, 0.1 g of the test material was melted and weighed in and 0.1, 0.5, 1.0, 2.0 and 10.0 g of 1-octanol were added to each weighted sample. The test material was completely solved giving clear solutions.

Applicant's summary and conclusion

Conclusions:
Under the study conditions, the test substance was miscible in 1-octanol in all proportions.
Executive summary:

A study was conducted to determine the 1-octanol solubility of the test substance, C12-18 and C18-unsatd. DEA, according to EU Method A.6. Under the study conditions, the test substance was miscible in 1-octanol in all proportions (Frishmann, 2010).

Categories Display