Registration Dossier
Registration Dossier
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EC number: 203-685-6 | CAS number: 109-59-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
In a study where an intraperitoneal injection of [1,2-14C]isopropyl oxitol was administered to rats and dogs and its metabolism and excretion determined, the substance was found to be rapidly metabolised. 88% was excreted from the body within 24hrs in the rat, 73% through kidneys, and 14% via the lungs as carbon dioxide. The major urinary metabolites were isopropoxyacetic acid (30% of urinary radioactivity), N-isopropoxyacetylglycine(46% of urinary radioactivity), and ethylene glycol (13% of urinary radioactivity). In the dog, only the first two metabolites were identified in the urine.
In a similar study, an intraperitoneal injection of [1,2-14C]isopropyl oxitol was administered to male and female rats and its metabolism and excretion determined.The material was rapidly metabolised and 87.65% was excreted from the body within 24hrs, 70.84% through the kidneys, and 12.41% via the lungs as carbon dioxide. Radioactivity found in the animal tissues at the end of the experiment accounted for 10.15% of the administered dose.
Both of these studies support the fact that isopropoxyethanol will have similar ADME characteristics to other ethylene oxide based glycol ethers. That is that it is readily absorbed following oral administration or inhalation and that dermal absorption (of vapour and liquid) can also be significant, depending on the skin area exposed. As a fully water miscible substance, it will be widely distributed throughout the body but will not accumulate. Metabolism is rapid (as demonstrated in the two available studies.) Metabolism is via oxidation either by the ADH or via the microsomal CYP mixed function oxidase systems (O-demethylation or O-dealkylation). The former is usually dominant and leads to the formation of isopropoxyacetic acid, which is eliminated via the urine. The second pathway leads to CO2, which is exhaled, via ethylene glycol. Conjugated species are also formed and eliminated in the urine via reaction with glucuronyl or sulpho transferases (ECETOC 2005)
The rate of isopropyl glycol ether penetration in vitro through human skin in vitro was experimentally determined according to the OECD guideline and measured at 240 ± 62ug/cm2/hr and in pig skin to be 123 ± 19ug/cm2/hr. The rate of flux did not change when the substance was present as a 50% aqueous solution in human skin and decreased by less than a factor of 2 at 50% aqueous solution in pig skin.
Reference
ECETOC (2005) The Toxicology of Glycol ethers and its Relevance to Man, 4th ed, vol I. Technical report 95, ECETOC, Brussels
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