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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
one drop of the liquid was admintered into the conjunctival sacs of 6 rabbits eyes, three of which were promptly washed.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(propyloxy)ethanol
EC Number:
220-548-6
EC Name:
2-(propyloxy)ethanol
Cas Number:
2807-30-9
Molecular formula:
C5H12O2
IUPAC Name:
2-propoxy-1-ethanol
Details on test material:
- Name of test material (as cited in study report): 2-)Propoxyethanol

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
1 drop/eye
Duration of treatment / exposure:
one drop of the liquid was admintered into the conjunctival sacs of 6 rabbits eyes, three of which were promptly washed.
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
6
Details on study design:
one drop of the liquid was admintered into the conjunctival sacs of 6 rabbits eyes, three of which were promptly washed.

Results and discussion

In vivo

Results
Irritation parameter:
other: observation
Remarks on result:
probability of moderate irritation
Remarks:
moderate to strong irritant
Irritant / corrosive response data:
The ocular irritancy of the compound was determined using a Standardized test administration of' one drop of liquid to the conjunctival sacs of 6
rabbit eyes, three of which were promptly washed. The compound was moderate to strong eye irritant causing slight to severe erythema and slight to moderate edema of the conjunctivae, iritis and staining of adnexae and cornea. Some degree of corneal opacity was seen in all eyes tested . All signs resolved by 14 days. Prompt irritation had a slight palliative effect.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Based on the results of the study the material was moderately toxic to eyes of rabbits. According to the EU CLP regulations (GHS Criteria), the substance would be classified as a Category 2
Executive summary:

The ocular irritancy of the compound was determined using a Standardized test administration of' one drop of liquid to the conjunctival sacs of 6 rabbit eyes, three of which were promptly washed. The compound was moderate to strong eye irritant causing slight to severe erythema and slight to moderate edema of the conjunctivae, iritis and staining of adnexae and cornea. Some degree of corneal opacity was seen in all eyes tested . All signs resolved by 14 days. Prompt irritation had a slight palliative effect.