Registration Dossier
Registration Dossier
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EC number: 205-745-7 | CAS number: 149-73-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- ECB
- Year:
- 2 000
- Bibliographic source:
- Iuclid4 data set, 18/02/2000
Materials and methods
Test guideline
- Guideline:
- other: Ames test
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Trimethyl orthoformate
- EC Number:
- 205-745-7
- EC Name:
- Trimethyl orthoformate
- Cas Number:
- 149-73-5
- Molecular formula:
- C4H10O3
- IUPAC Name:
- trimethoxymethane
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97, TA98, TA100
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 8, 40, 200, 1000, 5000 microgram per plate
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA97, TA98, TA100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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