Registration Dossier
Registration Dossier
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EC number: 700-393-5 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Details of toxic effects not reported other than lethal dose value.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of Delayed Neurotoxicity and Dose-Response Relationships of Phosphate Esters in the Adult Hen
- Author:
- Johannsen, F. R.; Wright, P. L.; Gordon, D. E.; Levinskas, G. J.; Radue, R. W. and Graham P. R.
- Year:
- 1 977
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY Vol. 41, Pg. 291-304 (1977)
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Undiluted test material was applied (dorsal) to rabbits to determine the LD50.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- biphenyl-2-yl diphenyl phosphate
- Cas Number:
- 132-29-6
- Molecular formula:
- C24H19O4P
- IUPAC Name:
- biphenyl-2-yl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): o-Xenyl diphenyl phosphate
- Composition of test material, percentage of components: no quantitative information is available on o-xenyl diphenyl phosphate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- Maximum dosage: 7.9 g/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7.9 other: g/kg
- Based on:
- not specified
- Remarks on result:
- other: rabbit
Any other information on results incl. tables
Details of toxic effects not reported other than lethal dose value.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (rabbit) >7.9 g/kg
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