Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 700-393-5 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Details of toxic effects not reported other than lethal dose value.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of Delayed Neurotoxicity and Dose-Response Relationships of Phosphate Esters in the Adult Hen
- Author:
- Johannsen, F. R.; Wright, P. L.; Gordon, D. E.; Levinskas, G. J.; Radue, R. W. and Graham P. R.
- Year:
- 1 977
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY Vol. 41, Pg. 291-304 (1977)
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- The test substance was applied peroral to rats and hens to determine the LD50.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- biphenyl-2-yl diphenyl phosphate
- Cas Number:
- 132-29-6
- Molecular formula:
- C24H19O4P
- IUPAC Name:
- biphenyl-2-yl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): o-Xenyl diphenyl phosphate
- Composition of test material, percentage of components: no quantitative information is available on o-xenyl diphenyl phosphate
Constituent 1
Test animals
- Species:
- other: rat, chicken
- Strain:
- other: Sprague-Dawley strain rats and White Leghorn adult hens
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: capsule
- Vehicle:
- corn oil
- Remarks:
- undiluted and corn oil solutions
- Doses:
- Maximum dosages: 15.8 (rat) and 10 g/kg (chicken)
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15.8 other: g/kg
- Based on:
- not specified
- Remarks on result:
- other: rat
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 other: g/kg
- Based on:
- not specified
- Remarks on result:
- other: chicken
Any other information on results incl. tables
Details of toxic effects not reported other than lethal dose value.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- - LD50 (rat) >15.8 g/kg
- LD50 (chicken) > 10g/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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