Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The effective concentration (EC50) value of 3-chloroaniline in microorganism (Escherichia coli) in a 12 hr study on the basis of growth inhibition effect was found to be 343 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 343 mg/L
Additional information
No. of studies were reviewed for toxicity to microorganisms from reliable sources having Klimisch rating 2.
The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
IGC50 |
99 mg/L |
Growth inhibition |
48 hrs. |
Tetrahymena pyriformis |
Experimental data from Toxicology methods for CAS : 108-42-9 |
2 |
EC50 |
343 mg/L |
Growth inhibition |
12 hrs. |
Escherichia coli |
Experimental data from Ecotoxicology and Environmental Safety for CAS : 108-42-9 |
3 |
EC50 |
100 mg/L |
Population |
24 hrs. |
Tetrahymena pyriformis |
Experimental data from Sci. Total Environ.for CAS : 108-42-9 |
Based on the studies summarized in the above table for the target substance 3-chloroaniline in microorganisms (Tetrahymena pyriformis and Escherichia coli),the endpoint value was found to vary between IGC50 = 99 mg/L and EC50 = 100 mg/L to 343 mg/L in a 12 hrs. to 48 hrs. study on the basis of growth inhibition and population effect.
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