Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-420-0 | CAS number: 7605-52-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex to Commission Directive 2004/73/EC (Official Journal No. L152, 30.4.2004). Part B, Method B.5 Acute Toxicity: Eye irritation/corrosion. OECD Guideline for Testing of Chemicals No.405 “Acute Eye Irritation/Corrosion”. Adopted 24 April 2002. EPA Healt
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1ml
- Observation period (in vivo):
- 15 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Time point:
- other: 1, 24, 48, 72 hr and 8, 15 days
- Score:
- 0 - 5
- Max. score:
- 5
- Irritation parameter:
- iris score
- Time point:
- other: 1, 24, 48, 72 hr and 8, 15 days
- Score:
- 0 - 1.7
- Max. score:
- 1.7
- Irritation parameter:
- conjunctivae score
- Time point:
- other: 1, 24, 48, 72 hr and 8, 15 days
- Score:
- 0 - 10
- Max. score:
- 10
Applicant's summary and conclusion
- Conclusions:
- The highest total mean score was 10.0 occurring at the 24 hour observation; accordingly under the criteria Kay and Calandra (1962) M3MC-Carboxylate was classified as “minimally irritating” to the eye.
- Executive summary:
The highest total mean score was 10.0 occurring at the 24 hour observation; accordingly under the criteria Kay and Calandra (1962) M3MC-Carboxylate was classified as “minimally irritating” to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
