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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC Methods for determination of toxicity, Annex Directive 92/69/EEC, OECD Guideline for Testing of Chemicals No. 402, EPA Health Effects Test Guidelines OPPTS 870.1200
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: The test substance was applied undiluted.
Duration of exposure:
24 h
Doses:
2000 mg/kg
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
There were no deaths and no systemic response to treatment in any animal.
Body weight:
The weight of each rat was recorded on Days 1 (prior to dosing), 8 and 15. Individual weekly bodyweight changes and group mean bodyweights were calculated.

No bodyweight gain was noted for one female (A9) on Day 8. All other animals were considered to have achieved satisfactory bodyweight gains throughout the study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute median lethal dermal dose (LD50) to rats of M3MC-Carboxylate was demonstrated to be greater than 2000 mg/kg bodyweight.
M3MC-Carboxylate is in Category 3 according to the EPA Health Effects Test Guidelines OPPTS 870.1000 Acute Toxicity testing EPA 712-C-98-189 August 1998.
Executive summary:

The acute median lethal dermal dose (LD50) to rats of M3MC-Carboxylate was demonstrated to be greater than 2000 mg/kg bodyweight.

M3MC-Carboxylate is in Category 3 according to the EPA Health Effects Test Guidelines OPPTS 870.1000 Acute Toxicity testing EPA 712-C-98-189 August 1998.