5-chloro-2-(4-chlorophenoxy)phenol;[DCPP]

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

other: Transformation product of Diclosan

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Screening test; No analytical monitoring; Information on the test system incomplete (test vessel, aeration, …); No information on test fish except for species; No information on concentration of solvent

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

4640-07-7

Cas Number:

4640-07-7

IUPAC Name:

4640-07-7

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): FAT 80221/A
- Physical state: white powder
- Analytical purity: > 99%
- Lot/batch No.: C-950/Thomas Maier
- Expiration date of the lot/batch: expiration date: 30 Sept 2010
- Storage condition of test material: at room temperature

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solution with solvent was prepared.
- Controls: yes (control and solvent control)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): N,N-DimethylFormamide(DMF)

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Details on test organisms:

TEST ORGANISM
- Common name: zebrafish

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Test conditions

Test temperature:

21.8 to 22.0 °C

pH:

8.3 to 8.5

Dissolved oxygen:

96% to 99% air saturation

Nominal and measured concentrations:

Nominal: 0 (control), 0 (vehicle control), 0.03, 0.1, 0.3, and 1.0 mg/L

Details on test conditions:

TEST SYSTEM
- Test vessel: no data
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1

TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: no data

OTHER TEST CONDITIONS
- Adjustment of pH: no data
- Photoperiod: no data
- Light intensity: no data

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mortality and behaviour after 24, 48, 72, and 96 h

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Details on results:

The fish in the highest test concentration (1.0 mg/L) were calm. No other sublethal effects were observed. Mortality was not observed in any of the treatments.