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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

Fathead minnows (Pimephates promelas) 30 d of age were exposed to dinoseb (2-sec-butyl-4,6-dinitrophenol) in flow-through tests.
Early life-stages of the fathead minnow (embryos, fry, and juveniles) were exposed to lower concentrations of each compound for a total of 64 d. The no effect concentration was estimated to lie between 14.5 and 48.5 µg/L.

Key value for chemical safety assessment

Additional information

Value for CSA= 14.5 and 48.5 µg/L.

- In the key study, Callet al, 1984, early life stages of the fathead minnow were exposed to concentrations of the test material for a total of 64 days. The 'no effect' concentration was estimated to lie between 14.5 and 48.5 µg/L for dinoseb. Neither herbicide was appreciably accumulated in fish tissue. The whole body bioconcentration factors for parent14C-dinoseb was 1.4. Rainbow trout (Salmo gairdneri) injected with radio-labelled dinoseb eliminated >83% of the radioactivity within 24h as a combination of parent compound and metabolites.

The reliability rating for this study is 2, according to the criteria of Klimisch, 1997 as the study is an adequately reported non-GLP study not conducted according to standard methodology.