Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No guideline followed. Atypical species of animal used.

Data source

Reference
Reference Type:
publication
Title:
Toxicity, Uptake, and Elimination of the Herbicides Alachlor and Dinoseb in Freshwater Fish
Author:
Call. D.J, et al
Year:
1984
Bibliographic source:
J. Environ. Qual., Vol 13, no. , 1984 pp. 493 - 498

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
in vivo metabolism study
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
yes

Test animals

Species:
other: fish
Strain:
other: Pimephales promelas & Salmo gairdneri
Sex:
not specified

Results and discussion

Any other information on results incl. tables

Dinoseb was readily eliminated by trout as both parent compound and as metabolites. Ninety percent of the herbicide injected into trout was recovered in the water within 24 h, of which 50% appeared to be parent compound by TLC. At least two polar metabolites and one or two metabolites less polar than dinoseb were present in the water. A similar metabolite profile was observed in bile, except that no parent compound was present. Insufficient quantities of metabolites were available for generation of mass spectra and GC/MS characterization. Mammalian studies have shown that dinoseb is readily metabolized.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Dinoseb is not highly bioconcentrated in fish tissue, and small amounts that may accumulate are readily eliminated when the exposure ends.
Executive summary:

In a series of studies investigating the acute toxicity, effects to early-life stages as well as uptake and elimination of dinoseb, rainbow trout weighing 100 to 150 g were injected with 37 kBq of 14C-labelled herbicide after exposure for 4 to 5 days to low levels of unlabelled compound. Fish were sacrificed after 24 hours.

Dinoseb was readily eliminated by trout as both the parent compound and as metabolites. Ninety per cent of the herbicide injected into trout was recovered in the water within 24 hrs, of which 50% appeared to be parent compound by TLC. At least two polar metabolites and one or two metabolites less polar than dinoseb were present in the water. A similar metabolite profile was observed in bile, except that no parent compound was present. Insufficient quantities of metabolites were available for generation of mass spectra and GC/MS characterization.