Registration Dossier
Registration Dossier
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EC number: 609-530-2 | CAS number: 38172-91-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test: Test was performed in principle as described in OECD Guideline 403.
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). 3 rats per sex were exposed to the vapours, generated by bubbling 200l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder. After 30 minutes this column was replaced by a new column filled with fresh test substance which was used unil the end of the exposure time. The total exposure time was 7h. The documentation of clinical signs was performed over a period of 14 days after exposure with the test substance. - GLP compliance:
- no
- Test type:
- other: Inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- Golpanol PAP
- IUPAC Name:
- Golpanol PAP
- Details on test material:
- - Name of test material (as cited in study report): Golpanol PAP / 2-Propyn-1-ol, compd. with methyloxirane
- Physical state: liquid
- Analytical purity: approx. 50%
- Impurities (identity and concentrations): < 1% Propargylalcohol, approx. 35% water, approx. 7% Propylenglycol, aprox. 7% higher alcoxylated products
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: male (mean): 273g, female (mean): 217g
- Fasting period before study: no
- Housing: 3 rats per cage
- Diet (e.g. ad libitum): ad libitum except of the time of exposure
- Water (e.g. ad libitum): ad libitum except of the time of exposure
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24°C
- Humidity (%): 30 - 70%
- Air changes (per hr): fully air-conditioned
- Photoperiod (hrs dark / hrs light): 12 hours / 12 hours
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged, no vehicle
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: compressed air, 200 liter / hour
- Treatment of exhaust air: disposal
- Temperaturein air chamber: 19 - 25°C - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- mean concentration estimated by reweighing
- Duration of exposure:
- 7 h
- Concentrations:
- mean concentration of test substance during 7 hours of exposure: 5.1 mg/l, estimated by reweighing
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: Inhalation hazard test
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality occured when rats were exposed for 7 hours to the saturated vapor of the test material
- Mortality:
- no mortality was observed
- Clinical signs:
- other: during exposure: mopping of the snout, red nose discharge, delayed pain reflex after exposure: bloody nose discharge
- Body weight:
- at beginning of the test: male (mean): 273, female (mean): 217
- Gross pathology:
- no pathological findings
Any other information on results incl. tables
No mortalities after 7-hour exposure to an atmosphere enriched with the test material.
Applicant's summary and conclusion
- Executive summary:
- No mortalities after 7-hour exposure to an atmosphere enriched with the test material.
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