Registration Dossier
Registration Dossier
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EC number: 614-557-8 | CAS number: 68515-81-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There is no information directly relating to nonanol, branched and linear. Key studies were chosen from studies on closely related linear or branched alcohols of similar chain length. The choice of key study was based on reliability and similarity of chain length. The data available from standard in vitro and in vivo genetic toxicity assays for all related substances show no evidence of mutagenic potential.
In some cases the CAS and chemical identity stated refer to the SDA nomenclature for this substance. In REACH substance identification it is necessary to be more specific as to the chain lengths present. Full details may be found in the CSR.
Short description of key information:
In vitro information:
Gene mutation (Bacterial reverse mutation assay / Ames test): the related substance 1-octanol was negative with and without activation in S. typhimurium strains TA 98 and 100 (similar to OECD TG 471)
Gene mutation (Bacterial reverse mutation assay / Ames test): the related substance C7, 8 and 9 Alcohols; predominantly linear: negative with and without activation in S. typhimurium strains TA 98, TA100, TA1535 and TA1537 (OECD TG 471)
Cytogenicity in mammalian cells: the related substance C12 and 13 alcohols; linear and monobranched, type 2: negative in CHO cells (OECD TG 473)
Mutagenicity in mammalian cells: the related substance 2-ethylhexan-1-ol was negative with and without activation in L5178Y mouse lymphoma cells (similar to OECD TG 476)
In vivo
Chromosome aberration study in rats: the related substance 1-dodecanol was negative in mice after oral administration (gavage) (similar to OECD TG 475)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Nonanol, branched and linear is a member of the category aliphatic alcohols. The category members contain no structural elements which may be of concern for potential mutagenic activity. In vitro tests on mutagenicity to bacteria and to mammalian cells over the carbon range (C6-22) of the long chain alcohols category members (primary aliphatic alcohols) and supporting substances (C5-C24-34). Evidence from in vivo studies on other category members supports the conclusion that these alcohols are not genotoxic in vivo. Negative data of reliability 1 or 2 in support of the conclusion that these alcohols are not genotoxic are available from in vivo studies on 2-ethyl hexanol (supporting) [negative chromosome aberration assay] and 1-dodecanol [negative micronucleus assay].
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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