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EC number: 220-290-4 | CAS number: 2702-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Acute oral study, LD50 > 900 mg test substance/bw.kg (367.5 mg a.i./bw.kg) (Coturnix coturnix japonica)
Dietary study, LC50 > 4028 mg test substance/kg food (1644 mg a.i./kg food) (Coturnix coturnix japonica)
Key value for chemical safety assessment
Additional information
No experimental data investigating the toxicity of sodium 2,4-dichlorophenoxyacetate (CAS No. 2702-72-9) to birds were available. Therefore, a conclusion on this endpoint was drawn based on the toxicity data of an analogue substance.
The acute toxicity of dimethylammonium 2,4-dichlorophenoxyacetate (CAS No. 2008-39-1) was investigated by Szentes (2001). This test was performed according to US EPA 850.2100 Avian Acute Oral Toxicity test (1996) and GLP. A single dose of the test item was administered by oral gavage to 50 birds (10 birds per dose group), followed by an observation period of 14 days. Mortality was reported only at the highest concentration tested (900 mg/bw.kg), whereas clinical symptoms (ruffled feathers, reduced activity, etc) were observed at the 323, 539 and 900 mg/bw.kg up to 3 days post-treatment. From that moment onwards, those symptoms remitted completely. Feeding consumption and body weight were not affected by treatment with the test item, except from values between days 0-3 at the 900 mg/bw.kg dose. The resulting LD50 was > 900 mg test substance/bw.kg (367.5 mg a.i./bw.kg) and the NOEL based on body weight and clinical observations, 193 mg test substance/bw.kg (78.8 mg a.i./bw.kg).
Additionally, the dietary toxicity ofdimethylammonium 2,4-dichlorophenoxyacetate (CAS No. 2008-39-1) was determined in a study by Gaborné (2001), conducted according to OECD Guideline No. 205: Avian Dietary Toxicity Test (1984), under GLP conditions. The test organisms (10 per replicate,Coturnix coturnix japonica) were fed for 5 days poultry standard diet, treated with the test item. Mortality, clinical symptoms, feed consumption and body weight were measured throughout the exposure and post-observation periods (3 days). No effects were reported, except for a reduction in body weight at the highest concentration tested (4028 mg/kg food) compared to control group values. Therefore, the LC50 value was determined to be over 4028 mg test substance/kg food (1644 mg a.i./kg food)
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