Registration Dossier
Registration Dossier
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EC number: 604-269-0 | CAS number: 14205-46-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable study performed according to GLP and European guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EWG (Amtsblatt der Europäischen Gemeinschaften Nr. L 251 vom 19.09.1984, S. 96) and proposal of the OECD updating panels of 1986-04-11
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- isopropyl (E)-3-aminobut-2-enoate
- EC Number:
- 604-269-0
- Cas Number:
- 14205-46-0
- Molecular formula:
- C7 H13 N O2
- IUPAC Name:
- isopropyl (E)-3-aminobut-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, Borchen, Germany
- Strain: Bor:WISW (SPF Cpb)
- Age at study initiation: adult (174 g males - 175 g females)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- 400
- Details on oral exposure:
- - Application volume: 10 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at least once daily (clinical signs, mortality) or once weekly (weight gain)
- Necropsy of survivors performed: yes - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: piloerection and increased diuresis up to 48 hours after dosing
- Gross pathology:
- no findings
Applicant's summary and conclusion
- Executive summary:
The acute oral toxicity of 3 -Aminocrotonsäurepropylester was low with an LD50 value of > 2000 mg/kg bw in rats. No mortality occurred and clinical signs became obvious in the first 2 days after treatment as piloerection and increased diuresis.
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