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EC number: 604-269-0 | CAS number: 14205-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (Rat-Wistar, GLP): LD50 > 2000 mg/kg
Inhalation (Rat-Wistar, GLP, OECD TG 403): LC50 > 6064 mg/m³
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable study performed according to GLP and European guidelines
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EWG (Amtsblatt der Europäischen Gemeinschaften Nr. L 251 vom 19.09.1984, S. 96) and proposal of the OECD updating panels of 1986-04-11
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, Borchen, Germany
- Strain: Bor:WISW (SPF Cpb)
- Age at study initiation: adult (174 g males - 175 g females)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days - Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- 400
- Details on oral exposure:
- - Application volume: 10 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at least once daily (clinical signs, mortality) or once weekly (weight gain)
- Necropsy of survivors performed: yes - Statistics:
- none
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: piloerection and increased diuresis up to 48 hours after dosing
- Gross pathology:
- no findings
- Executive summary:
The acute oral toxicity of 3 -Aminocrotonsäurepropylester was low with an LD50 value of > 2000 mg/kg bw in rats. No mortality occurred and clinical signs became obvious in the first 2 days after treatment as piloerection and increased diuresis.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well reported GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- additionally, an inhalation-risk test was performed
- GLP compliance:
- yes
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Strain: Bor:WISW (SPF-Cpb)
- Weight at study initiation: 170 - 190 g
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: at least 5 days - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- nominal concentration: 50.000 µl/m³ air
analytic concentration: 6064 mg/m³ - No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6 064 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- none
- Clinical signs:
- other: reduced respiratory frequency and unspecific symptoms
- Body weight:
- no changes
- Gross pathology:
- no findings
- Executive summary:
The acute inhalation toxicity of 3 -Aminocrotonsäureisopropylester, tested in a GLP-compliant study according to OECD TG 403, is low with an LC50 of > 6064 mg/m³ for male and female rats. No mortalities, no changes in body weight development and no necropsy findings became obvious. At the day of exposure the animals showed reduced respiratory frequency and unspecific symptoms.
In an inhalation-risk test with exposure of rats for 7 hours the saturated atmosphere of 657 mg/m³ was tolerated well by the animals.
Reference
In the inhalation-risk test the animals were exposed in 10l restrainers to a saturated test atmosphere (35 ml test substance at 20 °C was filled in a container with 3.5 cm diameter). Aircirculation: 3.3 L air per minute. Thus, the animals (5 males, 5 females) were exposed to a nominal concentration of 657 mg/m³ air for 7 hours.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity of 3 -Aminocrotonsäurepropylester was low with an LD50 value of > 2000 mg/kg bw in rats. No mortality occurred and clinical signs became obvious in the first 2 days after treatment as piloerection and increased diuresis.
The acute inhalation toxicity of 3 -Aminocrotonsäureisopropylester, tested in a GLP-compliant study according to OECD TG 403, is low with an LC50 of > 6064 mg/m³ for male and female rats. No mortalities, no changes in body weight development and no necropsy findings became obvious. At the day of exposure the animals showed reduced respiratory frequency and unspecific symptoms.
In an inhalation-risk test with exposure of rats for 7 hours the saturated atmosphere of 657 mg/m³ was tolerated well by the animals.
Justification for selection of acute toxicity – oral endpoint
only one study available
Justification for selection of acute toxicity – inhalation endpoint
only one study available
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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