Registration Dossier
Registration Dossier
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EC number: 203-139-7 | CAS number: 103-73-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The MAK Collection for Occupational Health and Safety
- Author:
- MAK Collection
- Year:
- 2 012
- Bibliographic source:
- MAK Value Documentation, 146–153, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An ocular irritation study was conducted for chemical on rabbits to determine adverse effects caused by the chemicals.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- phenoxybenzene
- Cas Number:
- 101-84-8
- Molecular formula:
- C12H10O
- IUPAC Name:
- phenoxybenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material: Diphenyl ether
- Molecular formula: C12H10O
- Molecular weight: 170.211 g/mol
- Substance type: Organic
- Physical state: Liquid
- Smiles: c1(Oc2ccccc2)ccccc1
-InChI:1S/C12H10O/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100mg
- Duration of treatment / exposure:
- single
- Observation period (in vivo):
- 24 hours till 21 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- - Area of exposure: conjunctival sac
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- fully reversible within: 21 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- The test chemical caused resulting corneal damage which persisted for more than 24 hours, but healed within 21 days.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test chemical caused resulting corneal damage which persisted for more than 24 hours, but healed within 21 days.
Hence, the test chemical can be considered to be irritating to eyes. - Executive summary:
An ocular irritation study was conducted to determine adverse effects caused by the chemical in rabbits
100mg of the test chemical was instilled into the eyes of 3 rabbits and observed for effects from 24 hours till 21 days.
The test chemical caused corneal damage which persisted for more than 24 hours, but healed within 21 days.
Hence, the test chemical can be considered to be irritating to eyes.
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