Registration Dossier
Registration Dossier
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EC number: 202-488-2 | CAS number: 96-20-8
Endpoint summary
Administrative data
Description of key information
Skin corrosivity assay on 2-aminobutanol
5-day Skin irritation assay on structural isomer 2-amino-2-methyl propanol
Eye irritation assay on 2-aminobutanol
Eye Irritation assay on structural isomer 2-amino-2-methyl propanol
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The studies available on the irritating potential of 2 -aminobutanol are poorly reported and of limited reliability. However they indicate that 2 -aminobutanol is potentially corrosive to skin and eyes. It is possible that were the corrosivity study on 2 -aminobutanol repeated according to today’s standards, it may be considered only irritant. However due to the high pH, and the existing information it seems appropriate to consider it as corrosive rather than repeat the studies.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Due to the limited nature of the data it is not possible to place 2 -aminobutanol in a specific category for corrosivity, however it is also not acceptable to repeat the studies solely for the purpose of doing so. Therefore the classification of R34 according to the Dangerous substance directive and Category 1B according to GHS is considered appropriate.
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