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Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB
Justification:

The available evidence on degradation, bioaccumulation potential, and toxicity for 2-aminobutan-1-ol

(2-AB) indicates that the screening criteria for persistence (P), bioaccumulation potential (B), and

toxicity (T) are not met. Based on the information described below for the relevant endpoints, 2-AB is

considered as not PBT/vPvB.

Summary conclusion on PBT or vPvB properties

Constituent

P/vP

B/vB

T

2-aminobutan-1-ol

EC no. 202-488-2

CAS no. 96-20-8

Readily biodegradable

(The Dow Chemical

Company, 2010)

Conclusion: Not P/vP

based on screening

criteria.

Measured log Pow is

-0.45 at 20°C (Lhotak, H.,

1996)

Conclusion: Not B/vB

based on screening

criteria.

LC50/EC50 values96 hour=

270 mg/L forLeuciscus idus

melanotus(ANGUS

Chemical Company, 1991)

LC50/EC5048 hour= 115 mg/L

forDaphnia magna

(ANGUS Chemical

Company, 2009)

EC5096 hr.= 0.91 mg/L

Pseudokirchneriella

subcapitata (ANGUS

Chemical Company, 2009)

Conclusion: Not T based on

screening criteria

Impurity

P/vP

B/vB

T

2-(methylamino)butan-1-

ol

EC no. 248-591-6

CAS no. 27646-79-3

ca. 1.4% (w/w)

Based on structural

similarity to 2-

aminobutan-1-ol, this

substance can be

considered readily

biodegradable. BIOWIN

version 4.10 predicts rapid

biodegradation.

Conclusion: Not P/vP

based on screening

criteria.

Estimated log Pow is

–0.24 (KOWWIN version

1.67)

Conclusion: Not B/vB

based on screening

criteria.

Based on structural

similarity to 2-

(methylamino)butan-1-ol,

this substance is expected

to have ecotoxicity

endpoint values greater

than the toxicity threshold

for T. Predicted acute

toxicity LC50/EC50values

for fish, water fleas, and

algae range from 5 to 400

mg/L (ECOSAR version

1.00).

Conclusion: Not T based on

screening criteria.