Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 931-319-1 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the bioluminescence of the marine bacterium Photobacterium phosphoreum by NaOH has been measured with the Microtox test system, resulting in a 15-minutes EC50 of 22 mg/L (Bulich et al, 1990). The 2-minute EC10 of NaOH for the freshwater ciliated protozoan Tetrhymena thermophila (endpoint studied: motility pattern) is 161 mg/L).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 22 mg/L
- EC10 or NOEC for microorganisms:
- 161 mg/L
Additional information
The above mentioned data can be used in a weight of evidence approach, however these data should be interpreted with caution, since the method is not accepted to be reliable and important study details are missing (Klimisch 3)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
