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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 3 reliability score was assigned since the documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Hydrotherapy of Chemical Burns
Author:
Bromberg et al.
Year:
1965
Bibliographic source:
Plast Reconstr Surg, 35, 85-95

Materials and methods

Principles of method if other than guideline:
Sodium hydroxide was applied to the back of 27 mice. Afterwards the area was irrigated for 1 hour with water at various time intervals.
GLP compliance:
no
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
mouse
Strain:
other: 54 A/He and C57 black adult mice
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: not described
- Age at study initiation: adult
- Weight at study initiation: 25-35 g


Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
TEST SITE
- Area of exposure: circular 2 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Afterwards the area was irrigated for 1 hour with water at various time intervals
- Time after start of exposure: no data


TEST MATERIAL
- Concentration (if solution): 50% NaOH


No. of animals per sex per dose:
27
Control animals:
not specified

Results and discussion

Mortality:
The mortality of the mice was 0; 20; 40; 80 and 71 % when they were irrigated immediately, 30 minutes, 1 hour, 2 hours or not at all after the application.

Applicant's summary and conclusion