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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study is rated a "4" because the study predates GLP and limited details are provided.

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth HF, Jr, et al
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J 23:95-107

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth H.F. et al. Am. Ind. Hyg. Assoc. J. 23:95-107
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Di-''isodecyl'' phthalate
EC Number:
247-977-1
EC Name:
Di-''isodecyl'' phthalate
Cas Number:
26761-40-0
Molecular formula:
C28H46O4
IUPAC Name:
1,2-benzenedicarboxylic acid, di-isodecyl ester
Details on test material:
IUCLID4 Test substance: other TS: unspecified DIDP isomer

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 4-5 wks of age
- Weight at study initiation: 90-120 g
- Diet (e.g. ad libitum): Rockland rat diet, complete

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:
14 day observation period following single dose administration
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 60 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
The test substance is assumed to have a low order of acute toxicity by the oral route.
Executive summary:
    
The LD50 of DIDP in rats is greater than 62,080 mg/kg (Smyth et al., 1962).