Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study is rated a "4" because the study predates GLP and limited details are provided.

Data source

Reference
Reference Type:
publication
Title:
A Toxicological Investigation of some Acute, Short-Term, and Chronic Effects of Administering Di-2-ethylhexyl Phthalate (DEHP) and Other Phthalate Esters
Author:
Lawrence WH, et al
Year:
1975
Bibliographic source:
Environ Res 9:1-11

Materials and methods

Principles of method if other than guideline:
other : not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Di-''isodecyl'' phthalate
EC Number:
247-977-1
EC Name:
Di-''isodecyl'' phthalate
Cas Number:
26761-40-0
Molecular formula:
C28H46O4
IUPAC Name:
1,2-benzenedicarboxylic acid, di-isodecyl ester
Details on test material:
IUCLID4 Test substance: other TS: DIDP with different CAS#

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 100 other: g/kg

Applicant's summary and conclusion

Conclusions:
The test substance has a low order of acute toxicity by the i.p route of exposure. The LD50 > 100 g/kg.