Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-417-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- testing stating date 1993-02-09; testing terminating date 1993-02-23; reporting date 1993-03-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically well performed study; Guideline study; GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
- EC Number:
- 940-417-3
- Molecular formula:
- C14H30O4 C16H34O5
- IUPAC Name:
- 5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material :Triethylenglykoldibutylether
- CAS: 63512-36-3
- Molecular formula : C14H30O4
- Molecular weight : 263 g/mol
- Physical state: liquid
- Storage condition of test material: in darkness at room temperature under chemical fume hood
- Solubility: 2g/L in water
- Melting point: -42 °C
- Boiling point: 283 °C
- Density: 0.9169 mg/l at 20 °C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml of the test material
- Duration of treatment / exposure:
- 4h
- Observation period:
- Observation at 24, 48 and 72 hours; in case of any findings at 72 hours the observation period is to be extended up to for 14 days.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks:
- within 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks:
- within 14 days
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No classification is assigned for the registration substance with respect to the endpoint skin irritation.
- Executive summary:
The skin irritation property of the registration substance was investigated according to the OECD Guideline 404. Three rabbits were treated topically with 0.5 ml triethylenglycoldibutylether (representative material for the registration substance). The animals exhibited transient erythema and edema that were fully reversible within 14 days of observation period. The obtained mean scores for erythema and edema were 1.3 and 0.2 respectively. Based on the obtained result the registration substance was found to be not irritating according to the EU criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
