Registration Dossier
Registration Dossier
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EC number: 265-181-2 | CAS number: 64742-78-5 A complex combination of hydrocarbons obtained by treating an atmospheric tower residuum with hydrogen in the presence of a catalyst under conditions primarily to remove organic sulfur compounds. It consists of hydrocarbons having carbon numbers predominantly greater than C20 and boiling above approximately 350°C (662°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline, GLP-compliant study. Adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Undiluted test sample (0.3 ml) was applied to two regions of clipped rabbit skin for 1 h under occlusion (Hill Top Chamber, held in place with impervious tape). Within 1 h of removal of the chambers, one site was irradiated with UV A light (320-400 nm; 10 J / square cm) while the other site was protected from irradiation (aluminium foil). Regions of negative (untreated) and positive (1% 8-methoxypsoralen) control skin were exposed concurrently to UV A radiation, and all skin reactions recorded using Draize criteria. Results were presented as the photoirritation index (reflecting the mean irritative response for UV-irradiated skin in the presence or absence of test sample).
- GLP compliance:
- yes
Test material
- Reference substance name:
- 64741-81-7
- Cas Number:
- 64741-81-7
- IUPAC Name:
- 64741-81-7
- Test material form:
- other: Viscous hydrocarbon liquid
- Details on test material:
- - Name of test material (as cited in Sponsor documentation): F-136, heavy thermocracked distillate
Constituent 1
Results and discussion
Any other information on results incl. tables
Results presented as the photoirritation index = (24 + 72 mean for erythema and oedema after treatment with test substance and UV irradiation) - (24 + 72 mean for erythema and oedema after UV irradiation without treatment with test substance).
Mean photoirritation index = 2.8
Time course for findings:
|
24 hr |
48 hr |
72 hr |
Erythema, -UV |
0.8 |
1.2 |
1.2 |
Erythema, +UV |
1.4 |
2.2 |
2.8 |
Oedema, -UV |
0.4 |
0.4 |
0.4 |
Oedema, +UV |
1.6 |
2.4 |
2.6 |
Applicant's summary and conclusion
- Conclusions:
- The sample had a moderate potential to evoke photoirritation.
- Executive summary:
In a photoirritation study, 0.3 mL of the test material (F-136, heavy thermocracked distillate; CAS# 64741-81-7) was dermally administered (undiluted) to the clipped dorsal skin of 5 New Zealand White rabbits and covered under occlusive dressing for a period of 1 hour. The animals were subsequently observed for a period of 3 days.
The mean photoirritation index was determined to be 2.8.
It was concluded that the heavy thermocracked distillate has a moderate potential to evoke photoirritation.
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