Registration Dossier
Registration Dossier
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EC number: 205-861-8 | CAS number: 156-62-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1959
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- Only very old public available literature without GLP and limited information.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the Calcium-cyanamide Poisoning. IV. Histopathological Studies on the Tissues of the Rabbit Poisoned due to Calcium-Cyanamide
- Author:
- Murakami, H.
- Year:
- 1 959
- Bibliographic source:
- Unknown Japanese Journal 28, 281-283 (1959)
Materials and methods
- Type of study / information:
- Histopathological examination of the rabbit after acute poisoning with calcium cyanamide.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Histopathological examination of the rabbit after acute poisoning with calcium cyanamide.
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium cyanamide
- EC Number:
- 205-861-8
- EC Name:
- Calcium cyanamide
- Cas Number:
- 156-62-7
- Molecular formula:
- CN2.Ca
- IUPAC Name:
- calcium cyanoazanediide
- Reference substance name:
- Calcium oxide
- EC Number:
- 215-138-9
- EC Name:
- Calcium oxide
- Cas Number:
- 1305-78-8
- Molecular formula:
- CaO
- IUPAC Name:
- oxocalcium
- Reference substance name:
- Carbon
- EC Number:
- 231-153-3
- EC Name:
- Carbon
- Cas Number:
- 7440-44-0
- Molecular formula:
- C
- IUPAC Name:
- carbon
- Reference substance name:
- Hematite (Fe2O3)
- EC Number:
- 215-275-4
- EC Name:
- Hematite (Fe2O3)
- Cas Number:
- 1317-60-8
- Molecular formula:
- Fe2O3
- IUPAC Name:
- diiron oxide
- Reference substance name:
- Urea
- EC Number:
- 200-315-5
- EC Name:
- Urea
- Cas Number:
- 57-13-6
- Molecular formula:
- CH4N2O
- IUPAC Name:
- urea
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- dioxosilane
- Reference substance name:
- Trisilicon tetranitride
- EC Number:
- 234-796-8
- EC Name:
- Trisilicon tetranitride
- Cas Number:
- 12033-89-5
- Molecular formula:
- N4Si3
- IUPAC Name:
- trisilicon tetranitride
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- Molecular formula:
- CaH2O2
- IUPAC Name:
- calcium dihydroxide
- Reference substance name:
- Aluminium oxide
- EC Number:
- 215-691-6
- EC Name:
- Aluminium oxide
- Cas Number:
- 1344-28-1
- Molecular formula:
- Al2O3
- IUPAC Name:
- aluminium oxide
- Reference substance name:
- Cyanoguanidine
- EC Number:
- 207-312-8
- EC Name:
- Cyanoguanidine
- Cas Number:
- 461-58-5
- Molecular formula:
- C2H4N4
- IUPAC Name:
- 2-cyanoguanidine
- Reference substance name:
- Calcium acetylide
- EC Number:
- 200-848-3
- EC Name:
- Calcium acetylide
- Cas Number:
- 75-20-7
- Molecular formula:
- C2Ca
- IUPAC Name:
- calcium ethynediide
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Test material form:
- solid: particulate/powder
- Details on test material:
- Kalkstickstoff (calcium cyanamide, technical grade)
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
impurity 6
impurity 7
impurity 8
impurity 9
impurity 10
impurity 11
Results and discussion
Any other information on results incl. tables
The histopathological findings in various tissues of the rabbit were as follows:
- In the liver, the cell infiltration was found in the Glisson's capsule and the Kupffer`s cells were proliferous and hypertrophic, but the liver cells remained at almost the normal condition.
- The mucous membrane of the stomach exhibited the diffuse necrosis
- The findings in the brain, heart, lung, spleen and kidney were normal
Considering the results, it can be concluded that the liver is an organ easily damageable due to the calcium cyanamide.
Applicant's summary and conclusion
- Conclusions:
- Considering the results, it can be concluded that the liver is an organ easily damageable due to the calcium cyanamide.
- Executive summary:
A male rabbit was twice administered into the stomach with 2 g of calcium cyanamide.
The histopathological findings in various tissues of the rabbit were as follows:
- In the liver, the cell infiltration was found in the Glisson's capsule and the Kupffer`s cells were proliferous and hypertrophic, but the liver cells remained at almost the normal condition.
- The mucous membrane of the stomach exhibited the diffuse necrosis
- The findings in the brain, heart, lung, spleen and kidney were normal
Considering the results, it can be concluded that the liver is an organ easily damageable due to the calcium cyanamide.
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