Registration Dossier

Administrative data

Description of key information

Following dermal application to the shaved , intact skin of 3 rabbits for 4 hours 1,2 -dichloronitrobenzene was evaluated as non-irritant (Hoechst AG 1988).
1,2 -dichloro-4 -nitrobenzene applied into the conjunctival sac of the eye of rabbits caused slightly irritating effects which were reversible within 72 hours post application (Hoechst AG 1988)

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Following dermal application to the shaved , intact skin of 3 rabbits for 4 hours 1,2 -dichloronitrobenzene was evaluated as non-irritant (Hoechst AG 1988).

1,2 -dichloro-4 -nitrobenzene applied into the conjunctival sac of the eye of rabbits caused slightly irritating effects which were reversible within 72 hours post application (Hoechst AG 1988)


Effects on eye irritation: slightly irritating

Justification for classification or non-classification

Based on the results of the valid studies there is no reason for classification