1,2-dichloro-4-nitrobenzene

Endpoint summary

Description of key information

Single oral application of 1,2 -dichloro-4 -nitrobenzene to male rats resulted in LD50 of 625 mg/kg bw. Signs of intoxication were disorder in balance, reduced general condition and death in prone position.(Hoechst AG 1975) Single oral application of undiluted,warmed up to 40 °C testsubstance (technical grade) to male and female rats yielded LD50 of 950 mg/kg bw . Signs of intoxication. weight loss, salivation, occular discharge and collaps (Monsanto 1978). Methemoglobinemia was shown in cats (Hoechst 1975).
There are no valid acute inhalation studies available.
Single dermal application of 1,2 -Dichloronitrobenzene to the shaved, intact back of 6 female rats caused no mortality and no clinical findings. Thus the LD50 > 2000 mg/kg bw is determined (Hoechst AG 1975).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

695 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

2 000 mg/kg bw

Additional information

oral route:

Single oral application of 1,2 -dichloro-4 -nitrobenzene to male rats resulted in LD50 of 625 mg/kg bw. Signs of intoxication were disorder in balance, reduced general condition and death in prone position.(Hoechst AG 1975) Single oral application of undiluted,warmed up to 40 °C testsubstance (technical grade) to male and female rats yielded LD50 of 950 mg/kg bw . Signs of intoxication. weight loss, salivation, occular discharge and collaps (Monsanto 1978). Methemoglobinemia was shown in cats (Hoechst 1975).

inhalation route:

There are no valid acute inhalation studies available. 1,2 -Dichloro-4 -nitrobenzene shall be registrated according Regulation (EC) 1907/2008 (REACH) Article 18 (transported isolated intermediate) and no studies are required according REACH Annex VII.

dermal route:

Single dermal application of 1,2 -Dichloronitrobenzene to the shaved, intact back of 6 female rats caused no mortality and no clinical findings. Thus the LD50 > 2000 mg/kg bw is determined (Hoechst AG 1975).

Justification for classification or non-classification

Might be harmful due to formation of methaemoglobin; absorption by dermal and/or inhalation exposure might be assumed due to the physical chemical properties.

Risk of cutaneous absorption. Risk of methaemoglobin formation even after skin contact (leads to increased classification).

Symptoms may be delayed.