Registration Dossier
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EC number: 202-764-2 | CAS number: 99-54-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Single oral application of 1,2 -dichloro-4 -nitrobenzene to male rats resulted in LD50 of 625 mg/kg bw. Signs of intoxication were disorder in balance, reduced general condition and death in prone position.(Hoechst AG 1975) Single oral application of undiluted,warmed up to 40 °C testsubstance (technical grade) to male and female rats yielded LD50 of 950 mg/kg bw . Signs of intoxication. weight loss, salivation, occular discharge and collaps (Monsanto 1978). Methemoglobinemia was shown in cats (Hoechst 1975).
There are no valid acute inhalation studies available.
Single dermal application of 1,2 -Dichloronitrobenzene to the shaved, intact back of 6 female rats caused no mortality and no clinical findings. Thus the LD50 > 2000 mg/kg bw is determined (Hoechst AG 1975).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- 695 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- 2 000 mg/kg bw
Additional information
oral route:
Single oral application of 1,2 -dichloro-4 -nitrobenzene to male rats resulted in LD50 of 625 mg/kg bw. Signs of intoxication were disorder in balance, reduced general condition and death in prone position.(Hoechst AG 1975) Single oral application of undiluted,warmed up to 40 °C testsubstance (technical grade) to male and female rats yielded LD50 of 950 mg/kg bw . Signs of intoxication. weight loss, salivation, occular discharge and collaps (Monsanto 1978). Methemoglobinemia was shown in cats (Hoechst 1975).
inhalation route:
There are no valid acute inhalation studies available. 1,2 -Dichloro-4 -nitrobenzene shall be registrated according Regulation (EC) 1907/2008 (REACH) Article 18 (transported isolated intermediate) and no studies are required according REACH Annex VII.
dermal route:
Single dermal application of 1,2 -Dichloronitrobenzene to the shaved, intact back of 6 female rats caused no mortality and no clinical findings. Thus the LD50 > 2000 mg/kg bw is determined (Hoechst AG 1975).
Justification for classification or non-classification
Might be harmful due to formation of methaemoglobin; absorption by dermal and/or inhalation exposure might be assumed due to the physical chemical properties.
Risk of cutaneous absorption. Risk of methaemoglobin formation even after skin contact (leads to increased classification).
Symptoms may be delayed.
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